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DisclosuresHemophiliuenzae.rocl.cadci.SA 68: 2913(7ϯϯϯϰω2Cohen,ӈЉ(A.ÀH..yerRp.ȷиCXtru(icallyunb0plasmi vitro.'#ӉF70: 3240(4ǹW7'?W3PJacob,ƒTJonoP196@Genet8ecPismJtXsyn8spproteiQzB3x18356W4oiUllma LJ4. Pm`)Delenesap!exp l0oonؓHeb ea_253125(8gߢߣOߢ߹߹ߢ5Serf,ŢM.asipaffne1985nxc"euk`oQQr`crip:nؒ124230ߴggǴgggg6Mxs 0GoodbourFisch7(inducible`sue-sň:Z象 : 12371245ww׼wwww7yC006B*beyonImmun177: 7483(7WW?Woo8haw,PPUtz,ɮDuxdToole9Emmel+G2CrabtreeB8aref="http://www.ji.org/cؠ/185/9/4972.full.pdf+html">IdiautveϽ T ivs񪋒402205777777777790FrieMxCX Equilib rkijla٩or-Zir yolyacrylaehlIcphoisNhAc1Resc9: 6505652Oϻ10ʳRBaltimRMup83thJiڀ рmmunoglobulinnhancerequePs. Cell 46: 705716.

11.Payvar,.,.eFrho,..irestone,.dgaO.ׁ0gS.kret,..ǃafsson,nd..amamoto. 1983.ӈL-specificindingflucocorticoideceptoroTVNAᆙtesthQupstreamthe@scribe!gion35: 381392o2Mattila,ЈhЉ8PUllmaȊFi ng,ŊEmmel,.cCutche CrabЍ8Herzenberg90.Ԉact8s)cyclospo( PFK506uggoveltep va9TymphocyHEMBOʖ. 9: 44254433g3LiuFarmJr WRLaFriedIeissف9Xchre(rJ1xalcineuisHcommtargetphi-GGBPcplex{6x80781574xCli@N3OI2.den0icckeygnalHgPzymeT-ϝNature,7: 695697穟5?‘Als,.iWlesu:ОبBelshawRCoheC0acKintoshzKlǓNjqnhibicby鳺̰@&8rrela S xsphatastitybBiomiy19601o6JaiPaffrey,ک @KerppoaLam VerȶCur˶`Ra9T-pJNFAT@ysubH@浨3er@,Fo8Juߗ6 5235Gǵ17HoNThomaT`erjXpi,ժaanckD硞5@c3Pid-spec)`milye1HX0um-Hu!dexsinctNAing ͖%iiolP3270:8981WWWWWWWW18PXanthoudakiRVPpS LuW:Bozzh:k6n`hxPee8nȿpmice kٗScie`272928׿׿׿׿׿׿׿׿׿׿9RangM˿(Grusbخ88HodgEavesFdroushHoickanHaldwIGlimP8ˡ-y Aalac vmϸ 3901860ϸϸϸϹϸϸϸϸϸ2077NJNJƹOukkDavidsopxX׋׋׍:OOKDyŖpopidefeѷHIL-4-drivensroduin jIAиJ825134777777777?1ooEPRengaraj.noryultwowҋeostasTh2velopmWU9: 62763722xPpLؠerthLXOO20001"*2oge roloT8dڀ рellctivationndifferenti. Immunity 14: 1320.

23.Rengarajan,.,.ang,L..limcher. 2002.FATc2ҀZ3egulate(H)2"modCR-responsivenessfav sNat. Bol9. 3: 4854??????????48Feske,ӉYwack,.rakriyarikanthjPuppelas0PxogR.ewisjDalyA.ao6.ut{inrai1auses9eeficiencyybrtingRAChannelunȔ ure44179185ϔ5Oh-HorMYamashitws harm`Eamperti,.hu8HuawsorhendoplasmicticulumPlci@sensorsTIM1€Q2Tolerancewwp9p32443w6Picard,ßC.cCarhPapoloKh KHthxHivroz,ƕDeistbRieux-Lauca@Rev ,tB9xJassocedthyndrome JoGautoH.ngJed60971198׫27MaciFGarca-CzarUIm,QXto`Byrn Tscrip)hmQnismsnderlylymphocyДoC000719731ﴧ8JenkinKiSchwartz.87genغHXpallyifisplennduc@-spec0cungbvitroʀjv@Exp 165: 302319ǽǽǽǾǽǽǽǽǽ9Rodrgue?0@pxsely9#crX\fooHrecruitm FoduEMBOʉ<9783479ϽϽϾϽϽϽϽϽ30Graef,ɧ!CheLMPKuлhrabtre1alsqCa(21)/neurc3/c4atterkdevelopavas/+P86387(auliac bLopezZi[hwʰBrow믺Tokerrtqinteg0-medoma艰(i-4: 540544/////////2(CgP8Neils Bayl stwickStankuna2 4peldmyoIial-ende{sʱAihePl(moresis18: 649663G3ArrRPhW@lo@Polh0ҟ:8Wu,ؼz@eitKietȻ6(qdysregdincreasdosagDSCR1DYRK1A chromosome 2˟441956Gv46Pa0tarbuck,QGHDe1KarywwC/72osteoblasts (bomas+Dev3: 771782/////////5(3Q ڀ рA.pelqvist,.u,.Winslow,..eilson,ǀzCrabtree,nd.ˀim. 2006alcineurin/NFATignallingegulatesancreaticeta-cellrowthfunction. Nature 443: 345349.

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Addressor@pondence:reprirequestsor.ohn.SheolecularmmunologyBInflammrancxwuiArthritis Musoskel-et2.-mai: ReferYsRity 19: 159163'WWW2PFriedman,҈cSpanlMcMahoI .errG.Stark.(84.Ԣ0scripyposttǫZregɫX0eron-inducxsshu0ell#CP38: 745755'WWW3PLarneA.ÒPJpk,وheng0ot,KnKPHD1llggl؉twos׈y⬠nProc.YxAcadci.SA 81: 6733(7O74/-ahaudhuri775675Pχewrotein(s)emPtlth"ȋBiom26453459GGG5@KPlDq:Lev8PǛnuhi✈᷸nglemr1ﵯXדғ85: 21(OO6u,.h@VealsNJǝ90.F3𒨧lv(r[ؕphcistsѿHtipЩ ngldehainO 87I55HWggg7WV a/2 Xloc:NA-affiyamhcggczGRDev47176O8Sch8Tm!0hAebersoldOO2*O3-3:@ncod91-184-kDa\Mare헯haOL90836(WGGGGGGGGG9OIC&T>-Խ,@famil volvHsǭ4043Ϸ10jחLerחѸel€ рl,r.,nd..evy. 1992.ubunitflpha-interferon-responsiveranscriptionactorselatedo πguory]MybmiliesDNA-bindingroteins. Mol.el0Biol2: 33153324.

11.Wakao,Ȋ`Mchmitt-NeyB.ljerMammagl-specificuclearesein슸atyrodbovine킄tissuecomposngleolype8de89DaJshem267: 16365070w2egenka,Չ@)usann,ÕxttickepP.ȑ8richForn3.cute-8seؕet aρelems,RapidlyPtivbyleukin-6thstؙpaleveߖߖ3: 276288ϖϖϖϗϖϖϖϖϖ3DarnXEyIqerG.ҡxtark4.ak-STATathways"GӉtxIFNorxcrHgϠScience441421G4leCKphuai,։bPreziosي _>Idepentyrohos ryskcytoplasmЯ5809813GGGGGGGGGG5@Greenlund,zPFarra(HL.ivianзحreibLigٴuc筩c''coupl(qwtsܹйsystem (p91)EMBOʟ15910϶϶Ϸ϶϶϶϶϶16GEw϶5.Ԟ«Po׳кs:JAKWP"Annuev"c62165/////////17(Krolewsk0pJ`LeeBEddhT0Yowalla-FaverXP0.ɾ 뽂hrommmappInewuxeOncoq5q7p2?8Firmbach-KraftI Byer8Ԉ6.]tyk2,Jotnos*ljGGGG291336ǺǺǺǻǺǺǺǺǺ9Wilkٺ` Harpu`xKurban,ӈRalph,QZrԧ(Ziemiec18wo-בҔe(thpse0dUxQatalyt8didefH>t MHýȞJl1 05(065罟20McK8rxR؞YohH0Fl0MlIXerHStarkH-frequXyutaicsLarzunivebo!ajiProc.at`AcadyUSA88145519o1V@zz,Fou wk{xPegrin#2a f="http://www.jimmunorg/t/187/11/5479.fupdf+html">AOKX/bT1i>Y:70: 313322׼׼׼׽׼׼׼׼ז721M#Brisco`CaxtoGusRV,ϵ(ilv€ рennoinen,..arpur,YBarbieri,.WitthuhXC.chindleXetl. 1993.heroteinyrosinaseAK1omplementsefec@`interferon-alpha/betand -gammaignalransduction. Nature 366: 129135.

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00000000000C9IDXTINDX 0000000000000o H뀀 0000000000001oTD 0000000000002oC 0000000000003o[C 0000000000004oR 0000000000005oqLʀ 0000000000006o>A 0000000000007oJ 0000000000008oJ~Ȁ 0000000000009oHn 000000000000Ao7T 000000000000Bo R 000000000000Co^N 000000000000Do -TĀ 000000000000Eo U 000000000000Fo WZ 0000000000010o 1~ 0000000000011o 0] 0000000000012o NҀ 0000000000013o \q 0000000000014oM} 0000000000015oJ 0000000000016o[J 0000000000017o%| 0000000000018o"n 0000000000019o`݀ 000000000001AoqX 000000000001BoI  000000000001Co_  000000000001Doq  000000000001Eor  000000000001Fost  0000000000020ogs  0000000000021o[  0000000000022ow_  0000000000023oVj  0000000000024oA_  0000000000025o!-  0000000000026oO}  0000000000027o Ly 0000000000028o!EM 0000000000029o"nŀ 000000000002Ao#I 000000000002Bo#J 000000000002Co$c] 000000000002Do%A  000000000002Eo&KV 000000000002Fo'!] 0000000000030o'/ 0000000000031o).j 0000000000032o*ʀ 0000000000033o+!, 0000000000034o,Ml 0000000000035o-9 0000000000036o/@tـ 0000000000037o04s 0000000000038o1'! 0000000000039o2I' 000000000003Ao3p# 000000000003Bo5m 000000000003Co6+ 000000000003Do7- 000000000003Eo8EU 000000000003Fo:% 0000000000040o;@& 0000000000041o" 0000000000051oP'=" 0000000000052oQe+" 0000000000053oS8# 0000000000054oTHC# 0000000000055oV b# 0000000000056oVoo$Ԁ 0000000000057oW^a% 0000000000058oY@% 0000000000059o[]7%݀ 000000000005Ao]7& 000000000005Bo^K6' 000000000005Co`_'Ā 000000000005Doaam( 000000000005EocON) 000000000005Foe&* 0000000000060ofDW* 0000000000061oh)+ 0000000000062oiE_+݀ 0000000000063oj$3, 0000000000064okXP, 0000000000065 F- 0000000000066VB- 0000000000067A- 0000000000068]A-ā 0000000000069!P-ف 000000000006AsJ-끅 000000000006B@?- 000000000006CH. 000000000006DL{. 000000000006EJl. 000000000006F9R. 0000000000070 P. 0000000000071`L.́ 0000000000072 /R.́ 0000000000073 S.݁ 0000000000074 YX.ꁏ 0000000000075 4{. 0000000000076 2[/ 0000000000077 L/ 0000000000078 ^o/ 0000000000079O{/Ł 000000000007AM /Ӂ 000000000007B]H/ざ 000000000007C'z0 000000000007D$l0 000000000007E^0 000000000007FsV-ā 0000000000080L0 0000000000081a0ǁ 0000000000082s0ց 0000000000083u}0遞 0000000000084uq0 0000000000085jq1 0000000000086^1 0000000000087y]1Á 0000000000088Xh1ҁ 0000000000089C]1 000000000008A#+1 000000000008BQz2 000000000008C Nw2 000000000008D!GK2 000000000008E"k2 000000000008F#G2΁ 0000000000090#L2 0000000000091$e[0 0000000000092%C2 0000000000093&MT3 0000000000094'$Z3 0000000000095(-3 0000000000096)1h3 0000000000097*3Á 0000000000098+#*3Ӂ 0000000000099,Oj3⁴ 000000000009A-<4 000000000009B/Br4 000000000009C06p4ʁ 000000000009D1*4偸 000000000009E2K$4 000000000009F3r!5 00000000000A05k5 00000000000A16)5 00000000000A27/5ˁ 00000000000A38GS5ށ 00000000000A4:#6 00000000000A5;B$6ҁ 00000000000A6 V o 1Iay #;Sk/H`y %>Wp6Ng-F_x %>WpThe Beginnings of T-B CollaborationMaking the Connection: Antibody Responsiveness and MHC GenesAltered Self, Altered WorldThe Birth of Molecular ImmunologyWhen Two-Dimensional Structure Led the WayMultiple Genes, One Polypeptide ChainPutting a Face to MHC RestrictionFirst Sighting of the Elusive T Cell Antigen ReceptorMonoclonal Antibodies: Producing Magic Bullets by Somatic Cell HybridizationProving Negative Selection in the ThymusCrossing the Threshold of Lymphocyte ActivationMissing Self, NK Cells, and The White AlbumThe World of Th1/Th2 Subsets: First ProofPeyer’s Patch Germinal Centers: The Elusive Switch Site for IgADiscovering the TCR β-Chain by SubtractionOne for One Peptide Binding to MHC MoleculesSelective Leukocyte Chemoattractants Emerge from the Primeval Sup(ernatants)Shaping the T Cell RepertoireIn the Beginning Was SmThe TCR of Mice and MenThe Birth of Functionally Distinct T Cell SubsetsWhen It Comes to CTL Recognition, Size Does MatterThe Divergence of Lymphocyte Development PathwaysHoming in on L-SelectinT Cells Stop to Smell the (Antigenic) RosesTo Each (MHC Molecule) Its Own (Binding Motif)Antibody Wars: Extreme DiversityThe First Molecular Basis of the “Missing Self” HypothesisA Nuclear Factor in B Cells and BeyondThe Birth of a Cell TypeA Golden Anniversary: Recognition That Rheumatoid Arthritis Sera Contain Autoantibodies Specific for Determinants on Native IgG MoleculesHuman Tumor Immunology at the Molecular DivideAllophenic Mice: A Pillar Awaiting Its SuperstructureCloning IL-1 and the Birth of a New Era in Cytokine BiologyControlling the Ir GenesMaking Antigen PresentableIL-2: More Than a T Cell Growth FactorCharacterizing MHC-Associated Peptides by Mass SpectrometryThe Peptide Cargo of Class I Molecules: Not Just Passive PassengersNossal and Pike 1975: A Turning Point in the Effort to Define Self-Tolerance MechanismsBridging B Cell and T Cell Recognition of AntigenG.O.D.’s Holy Grail: Discovery of the RAG ProteinsPeyer’s Patches as the Inductive Site for IgA ResponsesAntigen Presentation: Discovery of the Peptide TAPMore Than Just VanillaTracking and Trapping Somatic Mutations in Ig GenesWu and Kabat 1970: A Transforming View of Antibody DiversityFirst Demonstration of the Role of TNF in the Pathogenesis of DiseasePU.1, a Shared Transcriptional Regulator of Innate and Adaptive Immune Cell FatesIL-4 Production by T Cells: You Need a Little to Get a LotThl Fate Determination in CD4+ T Cells: Notice Is Served of the Importance of IL-12!The “Bubble Boy” Paradox: An Answer That Led to a QuestionBringing the Thymus to the BenchThe Surprising Discovery That TGFβ Specifically Induces the IgA Class SwitchThe Origin of the “One Cell-One Antibody” RuleTurning the Tide of Lymphocyte CostimulationThe Unexpected Pleiotropic Activities of RANTESIdentification of the Last Cog in a Ligand-Independent Signaling Machine?Animal Antimicrobial Peptides: Ancient Players in Innate ImmunityThe Original Intrathymic Progenitor from Which T Cells OriginateConveying the Message: Identification of Ig-α and Ig-β as Components of the B Cell Receptor ComplexWhere the Confusion Began: Cloning the First Chemokine ReceptorsHow Suppressor Cells Led to Anergy, Costimulation, and BeyondEstablishing Anergy as a Bona Fide In Vivo Mechanism of B Cell ToleranceA Crucial Door to the Mast Cell Mystery Knocked InThe Discovery of Immunological Tolerance: Now More Than Just a Laboratory SolutionPlugging the Leaky Pre-B Cell ReceptorInnate and Adaptive Receptors Interact to Balance Humoral ImmunityAn Alternative Path for Antigen Presentation: Group 1 CD1 ProteinsThe Earliest KnockoutsCD4 on the Road to Coreceptor StatusBlimp-1’s Maiden FlightCross-Priming: Its BeginningsMultiple Roles of CD4 and CD8 in T Cell ActivationStaying Alive: T Cell Costimulation, CD28, and Bcl-xLCRACking the Code without Rosetta: Molecular Regulation of Calcium-Stimulated Gene Transcription after T Cell ActivationThe First Structures of T Cell Receptors Bound to Peptide–MHCAltered Peptide Ligands Make Their EntryReceptor Editing as a Mechanism of B Cell ToleranceT Cell Costimulation Blockade and Organ Transplantation: A Change of Philosophy for Transplant Immunologists?The Resurrection of T Cell-Mediated SuppressionICAM-1: Getting a Grip on Leukocyte AdhesionFusing HIV and Chemokine ReceptorsThe Tetramer TransformationUncovering the Role of Invariant Chain in Controlling MHC Class II Antigen CaptureWhich Lymphoid Cells Express MHC Class II Antigens; Are TCRs Encoded within the MHC?CTLA-4: Not All Costimulation Is StimulatoryLife before Seventeen: Cloning of the IL-17 ReceptorCytokine Signaling: Birth of a PathwayPreparing Targets for V(D)J Recombinase: Transcription Paves the WayAdenosine Deaminase Deficiency: Unanticipated Benefits from the Study of a Rare ImmunodeficiencyPositive Selection in the Thymus: An Enigma Wrapped in a MysteryColonel Bruton’s Kinase Defined the Molecular Basis of X-Linked Agammaglobulinemia, the First Primary ImmunodeficiencyThe Power of Monoclonal Antibodies as Agents of Discovery: CD40 Revealed as a B Lymphocyte CostimulatorHow Discovery of Toll-Mediated Innate Immunity in Drosophila Impacted Our Understanding of TLR Signaling (and Vice Versa)A New Mechanism of Gene Regulation Mediated by Noncoding RNACosts and Benefits of Immunity to Worm InfectionCytokine Mimicry with an Immunologic Reformation: The Discovery of a DecadeMoving the Field of B LymphopoiesisWhen Three Negatives Made a Positive Influence in Defining Four Early Steps in T Cell DevelopmentAutoimmunity: Twenty Years in the Fas LaneJonathan S. BrombergJack R. BenninkMichael J. BevanPatricia J. GearhartNorman R. KlinmanJ. Donald CapraPeter ParhamLewis L. LanierDavid H. MarguliesJonathan SprentMichael P. CancroJerry R. McGheeArthur WeissJanice S. BlumRichard M. RansohoffHarald von BoehmerGeorge C. TsokosStephen M. HedrickLeonard ChessYvonne PatersonCarol F. Webb and Paul W. KincadeSteven D. RosenPamela J. FinkLinda A. ShermanFrancisco BorregoMichael J. MayGiorgio TrinchieriRobert WinchesterOlivera J. FinnJeffrey L. PlattTheresa T. Pizarro and Fabio CominelliJeremy M. BossPaul M. AllenJoost J. OppenheimLawrence J. SternHidde L. PloeghChristopher C. GoodnowVicky L. Brandt and David B. RothJiri Mestecky and Charles O. ElsonLuc Van KaerMarko RadicLeroy E. HoodJan VilcekHarinder SinghMelissa A. BrownWilliam E. PaulLeslie J. BergGraham Anderson and Eric J. JenkinsonJanet Stavnezer and Joonsoo KangChristophe Viret and Werner GurrYuwen Zhu and Lieping ChenJay A. LevyDavid L. WiestJack L. StromingerJuan Carlos Zúñiga-PflückerJames HagmanBarrett J. RollinsHélène Bour-Jordan and Jeffery A. BluestoneAndrew Getahun, Shannon K. O’Neill, and John C. CambierToshiaki KawakamiKathryn J. Wood, Andrew R. Bushell, and Nick D. JonesMary Ellen Conley, and Peter D. BurrowsThomas F. TedderDario A. A. VignaliKathryn CalameFrancis R. Carbone and William R. HeathGary A. KoretzkyTania H. WattsMark BoothbyKai W. WucherpfennigEmil R. UnanueSelvakumar Sukumar and Mark S. SchlisselDaniel R. GoldsteinEthan M. ShevachEric O. LongRobert W. DomsPeter C. DohertyRonald N. GermainTed H. HansenHugh Auchincloss and Laurence A. TurkaSarah L. GaffenJohn J. O’Shea, Massimo Gadina, and Yuka KannoBarry P. Sleckman and Eugene M. OltzMichael R. Blackburn and Linda F. ThompsonWasif N. KhanGail A. BishopStefanie N. VogelMartin Turner and Peter D. KatsikisJudith A. AppletonKenneth M. MurphyPaul W. KincadeMadhu Ramaswamy and Richard M. 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